A new study published in the Annals of Neurology is among the first to link sound sensitivity in people with chronic back pain to measurable changes in the brain - and to show those changes can improve with therapy.

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The first mechanism that PBMs use is formulary leverage. Drug manufacturers that want preferred formulary placement—or to avoid exclusion from coverage—must offer better prices. That leverage for PBMs depends on a credible threat: lower your price or lose access to patients.